Skip to content

Author: lalanquist

Published on
3D Printers on Himmelfarb Library First Floor ©Himmelfarb Library, 2022

3D printing – what is it? It is a method of production, also known as additive manufacturing, in which software guides a machine to craft a 3D object, often with a high level of detail. This, however, is a very generalized definition. It is easy to assume that there is only one kind of 3D printing, but on the contrary: there are many different types of 3D printing, which can be referred to as “processes.” This post seeks to elaborate upon the different 3D printing processes, from the traditional Fused Deposition Modeling that you can find here at Himmelfarb Health Sciences Library, to the more unusual powder bed 3D printing, which is often used in the production of metal objects.

If you difficultly visualizing any of these types of 3D printing processes while reading this piece, check out Horne & Hausman’s 3D Printing for Dummies Chapter 2: Exploring the Types of 3D Printing. This post will describe these processes using more current terms, but this chapter has clear diagrams and illustrations, as well as some additional information about how various 3D printing processes function.

The most popular process of 3D printing is Fused Deposition Modeling, often referred to as FDM printing. This process produces 3D objects by heating up long strings of plastic material (aka: spools of filament), fusing it to the base platform of the printer, then continuing to build it up layer by layer using that same fusion process. Another way of looking at FDM printing is that it’s akin to a highly-nuanced hot glue gun (Horne & Hausman, 2018). There are also variants of FDM printers that utilize pellets instead of filament spools (Volpato et al., 2015), as well as those that use a cold semi-liquid mixture like what you might see with large-scale 3D printed houses that use concrete extrusion (Borg Costanzi et al., 2018).

FDM printing has some limitations. When the filament is in a moldable state during FDM printing, it extrudes through a nozzle, which is almost always moved along X and Y axes like what you might see on a crane game. Because of those movement restrictions, this process is weaker compared to its alternatives when it comes to items that have overhangs or details on an object’s underbelly. The machine is not so sensitive to be able to tell the difference between the 3D printers’ base platform, the previously-placed layers, and open air, so the printer needs the guiding software to give the digital object file (which you can think of as a map or a layout) structures known as “supports” which are designed to be removable. When those supports are removed, it is not uncommon to see score marks on the places where it touched, and in some cases, the area is so narrow that it’s impossible to remove those supports (Horne & Hausman, 2018).

Supports are less of a concern with Stereolithography Apparatus 3D Printing, also known as SLA printing. This 3D printing process produces 3D objects by aiming a laser up into a vat of liquid photopolymerizing resin. Photopolymerizing means that the liquid will transform into a solid when light of a certain wavelength touches it. Unlike FDM printers, which move the entire nozzle horizontally, SLA printers keep the laser fixed in one place, but change the angle. As the software instructs the laser to solidify certain portions of the vat of resin, the object is raised up and out of the vat by a component called the “elevator.” In the case of SLA printers, supports are not needed in order to hold up layers that have overhangs, but instead to keep the object attached to the elevator. SLA printers allow for more complex structures with holes, divots, and overhangs without using up as much filament and without causing scoring marks, and they often manage to print simple objects faster than FDM printers (Horne & Hausman, 2018).

SLA printing has its own downsides to keep in mind. For one, SLA printers tend to be more expensive than FDMs, and they require extra equipment, such as curing stations. Once the object is lifted up and out of the vat, it exists in a semi-cured state and is sticky. It needs to be treated with UV light to finish it. This makes not only cost, but space a concern, particularly since there is liquid resin involved, which requires special storage and disposal methods (Horne & Hausman, 2018).

Powder bed printing, also known as binder jet printing, likewise has some advantages at the cost of specialized set-up requirements. During this 3D printing process, a printer head moves horizontally along X and Y axes like with FDM printing, dropping a liquid binding material onto a powder that covers the printers’ base platform. When the binder comes in contact with the powder, a chemical reaction occurs that solidifies it. Since this process requires the use of fine particles which could be made of metal, plastic, sand, or even plaster, powder bed printers often require hoods and filters to prevent users from breathing in potentially harmful materials. An alternative method of powder bed printing uses a laser in the place of the binding liquid, which burns the powder to solidify it, which adds to the amount of safety equipment required (Horne & Hausman, 2018).

The finished product requires a step known as “depowdering” which can be done by hand with brushes and through automated vibration. Manual depowdering with brushes takes a significant amount of time, whereas automated vibration tools tend to be rather expensive. If you want to learn more about depowdering, this webpage by German depowdering manufacturer Solukon could be of help (Solukon, n.d.).

Powder bed printing is incredibly fast compared to FDM and SLA printing, and it has the added benefit of being able to produce metal objects swiftly. Additionally, this method does not require the use of supports, since the underlying layers of powder that were not activated by the binding chemical or laser can still support the weight of the rest of the object, despite the fact that the head of this kind of printer generally stays on X and Y axes like FDM printers (Horne & Hausman, 2018).

We would be remiss to not mention bioprinting, a process that technically falls under the umbrella of 3D printing which produces natural tissue, often for the sake of testing medications. The process of bioprinting starts by packaging certain types of cells taken from a biopsy into pellets the size of a micrometer or within a liquid that keeps the cells alive. Next, these packaged cells are combined with nutrients and a support material known as a matrix; this combination is known as a bioink. This bioink is then put into place layer by layer by the printer which is guided by software that interprets CT scans and MRIs. Up to this point, bioprinting fits the description of 3D printing, though the materials used are beyond the norm (Wei et al., 2020).

This is where bioprinting diverges, though. Rather than cooling down or solidifying and going off to the post-processing clean-up stage, the cells consume the nutrients and grow within the matrix. Pressure and chemical stimuli are added very carefully to nudge the cells to grow in the intended ways, and chemicals known as bioreactors are added as well to increase the speed of cell growth. There is no kind of 3D printing that is like this, simply because this part of the bioprinting process is less reliant on 3D printing methods and more on natural process of life: consumption, reproduction, and maturation (Wei et al., 2020).

Additional niche 3D printing processes also exist. Laminated Object Manufacturing (LOM) is a process that builds up laser-cut layers of paper, metal foil, or plastic film that has been coated with chemicals of choice. This process uses cheap, readily available materials and allows for additional customization, as the material color can change between layers (Horne & Hausman, 2018). Unfortunately, non-industrial LOM printer manufacturers are few and far between, as they are outpaced in popularity by FDM and SLA printers.

RoboCasting, a method of 3D printing similar to FDM printing which uses a paste made up of materials such as glass or ceramic, which either hardens on its own or needs to be baked. In their work, “3D Printing Bioinspired Ceramic Composites”, Feilden et al. explain how RoboCasting functions and how it can be used to mimic natural materials such as bone and shell (Feilden et al., 2017). This has some benefits for medical sciences through the development of implants such as biodegradable bone scaffolds that can aid during the healing process of bones, which you can learn more about in this study by Lei et al. (Lei et al., 2020).

Each of these 3D printing processes has strengths and weaknesses. Some may be faster, others may be more precise, and others still may be cheaper. This variability makes some more suitable for certain applications than others. FDM, for instance, because of its popularity, limited cost, and low barrier to entry, makes it a perfect choice for early-stage prototyping, whereas powder-bed printing may be more suited for an industrial environment. With 3D printing, the sky is truly the limit, particularly since new printers are being developed each year.

Want to try out 3D printing yourself? We are proud to announce that we have moved to a free-to-print policy and will no longer be charging cost-recovery fees for most print jobs. Some limitations apply, so make sure to consult our 3D Printing at Himmelfarb guide or full policy for the full details.

To learn more about our 3D printing service or to place a request, please visit our 3D Printing at Himmelfarb guide, or contact Brian McDonald (bmcdonald@gwu.edu) for more information.

References:

Borg Costanzi, C., Ahmed, Z. Y., Schipper, H. R., Bos, F., Knaack, U., & Wolfs, R. J. H. (2018)   3D printing concrete on temporary surfaces: The design and fabrication of a concrete shell structure, Automation in construction, 94, p. 395-404 https://doi.org/10.1016/j.autcon.2018.06.013

Feilden, E., Ferraro, C., Zhang, Q., García-Tuñón, E., D'Elia, E., Giuliani, F., Vandeperre, L., & Saiz, E. (2017).  3D printing bioinspired ceramic composites, Scientific Reports, 7(1), p. 1-9. https://doi.org/10.1038/s41598-017-14236-9

Horne, R. & Hausman, K. K. (2018). Exploring the types of 3D printing. 3D Printing for Dummies. https://ebookcentral.proquest.com/lib/gwu/detail.action?docID=4856326 

Lei, L., Wei, Y., Wang, Z., Han, J., Sun, J., Chen, Y., Yang, X., Wu, Y., Chen, L., & Gou, Z. (2020).   Core–shell bioactive ceramic robocasting: Tuning component distribution beneficial for highly efficient alveolar bone regeneration and repair, ACS biomaterials science & engineering, 6(4), p. 2376-2387. https://doi.org/10.1021/acsbiomaterials.0c00152

Solukon. (n.d.). Automating depowdering in 3D printing. Retrieved May 8. 2022 https://www.solukon.de/en/news/festo-and-solukon/

Volpato, N., Kretschek, D., Foggiatto, J. A., & Gomez da Silva Cruz, C. M. (2015)  Experimental analysis of an extrusion system for additive manufacturing based on polymer pellets,  International journal of advanced manufacturing technology, 81(9-12), p. 1519-1531. https://doi.org/10.1007/s00170-015-7300-2

Wei, S., Starly, B., Daly, A. C., Burdick, J. A., Groll, J., Skeldon, G., Shu, W., Sakai, Y., Shinohara, M., Nishikawa, M., Jang, J., Cho, D., Nie, M., Takeuchi, S., Ostrovidov, S., Khademhosseini, A., Kamm, R. D., Mironov, V., Moroni, L., Ozbolat, I. T. (2020). The bioprinting roadmap. Biofabrication, 12(2). https://doi.org/10.1088/1758-5090/ab5158

Published on
Empty hospital beds in a poorly lit room
Empty Hospital Beds
Pixabay, 2016

In an effort to remain accountable to communities who have been negatively impacted by past and present medical injustices, the staff at Himmelfarb Library is committed to the work of maintaining an anti-discriminatory practice. We will uplift and highlight diverse stories throughout the year, and not shy away from difficult conversations necessary for health sciences education. To help fulfill this mission, today's blog post highlights transgender healthcare equity.

Author notes 

The topics presented in this article may be difficult and/or retraumatizing for some readers. Subject matter includes medical neglect, transphobic harassment, usage of slurs, medical misdiagnosis, death of a Black transgender women by medical neglect, and cancer. 

While some of the sources cited in this article are from over a decade ago and may use outdated terminology and may misgender the individuals discussed in them, this article was written by a transgender member of Himmelfarb staff, who has used appropriate language in the article itself.

August 7th, 1995. Washington, DC. 

A 24 year old woman named Tyra Hunter was critically wounded in a car accident when another driver ran a stop sign (Bowles, 1995). Once first responders came on the scene and assessed the situation, instead of treating her properly, they mocked and degraded her (Remembering Our Dead, 2019). When she was finally brought to the emergency room at DC General Hospital, she was given a paralytic and slowly bled out (Fox, 1998). The delay in treatment and degrading comments took place because she was a black transgender woman.

Tyra Hunter’s case is, perhaps, one of the more extreme instances of medical transphobia and healthcare inequity. That said, Tyra Hunter is one of many transgender people who have been victimized by anti-transgender prejudice – both personal and systemic – in healthcare. 

From avoidance of medical care due to fear, to biased diagnoses from prejudiced professionals, to even the blatant transphobia that first responders directed at Tyra Hunter, transgender people – particularly for Black transgender women – frequently lack access to quality healthcare. In this post, we will review the most common ways prejudice and cultural incompetency impact transgender patients, and we will consider ways medical professionals can provide equitable healthcare to transgender individuals.

Medical transphobia can take many forms, and not all of them are as blatant as what Tyra Hunter experienced on the day of her death in 1995. Even microaggressions, when experienced over long periods of time, can cause transgender patients to avoid or delay seeking treatment. A study by Seelman et al. in the journal Transgender Health found that among transgender participants, “those reporting a noninclusive PCP or who delayed needed medical care because of fear of discrimination were less likely to have had a routine checkup in the past 2 years” (Seelman et al., 2017, p. 25). This is supported by a study by Jaffee et al., which found that “1 in 3 transgender respondents delayed needed medical care for an illness or injury due to discrimination” (Jaffee et al., 2016, p. 1012), and that “the odds of delaying needed care was approximately 4 times greater for those who reported having to teach their provider about transgender people” (Jaffee et al., 2016, p. 1012).

This fear of medical discrimination is by no means irrational. A study by Rodriguez et al. analyzing data from the National Transgender Discrimination Survey which included over 6000 participants, found that “more than one-third of transgender participants reporting having experienced discrimination in health-care settings” (Rodriguez et al., 2017, p. 980), wherein discrimination was defined as, “physical abuse, verbal harassment, and/or denied equal treatment” (Rodriguez et al., 2017, p. 975). Of note here is that this number parallels Jaffee et al.’s reported 1 in 3 transgender respondents delaying treatment.

Transgender patients’ lack of trust is also attributed to “Transgender Broken Arm Syndrome,” which occurs when healthcare providers attribute unrelated medical issues to a patient’s transgender identity or transition-related care. The colloquial term comes from the scenario where a transgender patient might go into the doctor for a broken arm, but the healthcare provider questions to the patient about their gender instead. Jennifer Kelley describes this kind of scenario with a patient named Cam in the article, Stigma and Human Rights: Transgender Discrimination and Its Influence on Patient Health. Cam wanted to see the doctor about a chronic issue unrelated to her transness, and perhaps discuss hormone replacement therapy, but the provider instead questioned her about her identity, gave her a pamphlet on HIV, and told her to find a specialist (Kelley, 2021). 

Another example of a transgender patient who was not able to access appropriate quality healthcare occured when Jay Kallio, a transgender man in his 50s living in New York, was discovered to have an aggressive form of breast cancer (Buxton, 2015). After receiving a mammogram and a biopsy, Kallio did not hear from his physician for many weeks. When he finally heard about his diagnosis, it was from the medical professional who performed the biopsy, who was shocked to hear that Kallio’s physician, a surgeon at a major New York hospital, had not informed him of the swiftly-worsening cancer. Kallio struggled to get in contact with this physician, and when he did, the surgeon began the conversation by stating that he wanted to send Kallio to a psychiatrist for his identity. Eventually, Kallio was thankfully able to transfer his case to another surgeon, and even beat the cancer in 2008, though he later succumbed to lung cancer in 2016. (Jay Kallio, n.d.) Ultimately, Kallio’s case is one that serves as a reminder of the very real potential consequences for medical transphobia.

There are, however, some of the most wretched instances of transphobia that involve harassment and blatant cruelty, such as what happened to Tyra Hunter. Another such case is that of Robert Eads, a transgender man who was taken to the emergency room in Georgia in 1996 after passing out. When he was diagnosed with ovarian cancer, he was refused treatment by more than a dozen medical practitioners. By the time he was accepted by the hospital of the Medical College of Georgia in 1997, the cancer had metastasized, and no treatment would have been able to save his life (Ravishankar, 2013). He died in 1999, and his story is told in the 2001 documentary, Southern Comfort, named after a popular transgender gathering that he spoke at after his prognosis (“Robert Eads”, 2007). His case is more similar to that of Jay Kallio than Tyra Hunter’s, but Eads’ slow and painful death was the result of medical transphobia in action.

Even the late transgender activist and author of the well-revered Stone Butch Blues, Leslie Feinberg (who used the neopronouns ze/hir), has discussed the transphobia ze faced after seeking treatment. In zir 2001 work, “Trans Health Crisis: For Us It’s Life or Death”, ze detailed how hospital staff gathered around zir, calling Feinberg “it” and “martian”. Feinberg chose to leave the hospital in question without being treated, and thankfully the illness ze had was not life-threatening, as it had been for Tyra Hunter and Robert Eads (Feinberg, 2001).

Knowing what we do about medical transphobia, how can healthcare professionals enact change within the healthcare system, ensure that transgender patients are treated equitably and ethically, and rebuild trust with the transgender community? 

Leslie Feinberg urges in zir aforementioned work that decisions related to transgender patients involve transgender and gender variant people of all kinds. Ze made recommendations large and small, some of which have been implemented already. One of the simplest, which has been picked up by quite a few healthcare professionals, is to “refer to patients by their first and last names, not Mr. or Ms., sir or ma'am.” Another is a call for institutional standards (Feinberg, 2001), such as the Standards of Care developed by the World Professional Association for Transgender Health (WPATH). This comprehensive document acts as a guideline for health care professionals “to provide clinical guidance for health professionals to assist transsexual, transgender, and gender nonconforming people with safe and effective pathways to achieving lasting personal comfort with their gendered selves, in order to maximize their overall health, psychological well-being, and self-fulfillment.” (Standards of Care, 2012, p. 1)

Medical education has also been shown to have significant gaps in coverage of transgender healthcare. Fung et al. performed a qualitative review of Toronto medical residents’ knowledge and confidence in transgender care in 2016. The results indicated that residents had limited exposure to formal training in transgender medicine, as well as few mentors within their specializations who had enough knowledge to confidently educate or advise on such topics (Fung et al., 2020). If you’d like to learn more about the gaps in transgender health education, Korpaisarn et al.’s Gaps in transgender medical education among healthcare providers reviews a number of studies on the subject and follows with a section on effective interventions, including the use of WPATH’s Global Education Initiative (GEI), which offers training and certification courses on transgender healthcare (Kopaisarn et al., 2018).

Healthcare professionals should stay up to date on legislative matters. Our previous article for Transgender Day of Visibility discussed this at length and included a number of resources for education and for action. If you would like to learn more about the legal side of transgender health, that piece would be a good starting point. Likewise, if you would like to learn more about some terminology related to transgender individuals in a healthcare setting or about how to build rapport with transgender patients or otherwise equitably treat transgender patients, Klein et al.’s Caring for Transgender and Gender-Diverse Persons: What Clinicians Should Know, is another useful resource.

Unfortunately, transphobia may persist in society and healthcare. It is unfortunately not enough to educate ourselves alone on matters of inequity and bias; the best way to support transgender patients is to speak out against transphobia when you see it. There will be times when speaking out is difficult, but when those moments happen, please remember that if even a single person had taken action, Tyra Hunter may have survived.

References

Bowles, S. (1995, December 10) A Death Robbed of Dignity Mobilizes a Community, Washington Post. https://www.washingtonpost.com/archive/local/1995/12/10/a-death-robbed-of-dignity-mobilizes-a-community/2ca40566-9d67-47a2-80f2-e5756b2753a6/ 

Buxton, R. (2015, June 15) This Trans Man's Breast Cancer Nightmare Exemplifies The Problem With Transgender Health Care, HuffPost. https://www.huffpost.com/entry/transgender-health-care_n_7587506

Feinberg, L. (2001)  Trans health crisis: For us it's life or death, American Journal of Public Health, 91(6), p. 897-900. https://doi.org/10.2105/AJPH.91.6.897

Fox, S. D. (1998, December 12) Damages Awarded after Transsexual Woman's Death. Polare. Internet Archive. https://web.archive.org/web/20140324052938/http://www.gendercentre.org.au/resources/polare-archive/archived-articles/damages-awarded-after-transsexual-womans-death.htm

Fung, R., Gallibois, C., Coutin, A., & Wright, S. (2020) Learning by chance: Investigating gaps in transgender care education amongst family medicine, endocrinology, psychiatry and urology residents, Canadian Medical Education Journal, 11(4), p. e19-e28. https://doi.org/10.36834/cmej.53009

Jaffee, K. D., Shires, D. A., & Stroumsa, D. (2016) Discrimination and delayed health care among transgender women and men, Medical Care, 54(11), p. 1010-1016. https://doi.org/10.1097/MLR.0000000000000583

Jay Kallio. (n.d.) Compassion and Choices. https://compassionandchoices.org/stories/jay-kallio/

Kelley, J. (2021) Stigma and Human Rights: Transgender Discrimination and Its Influence on Patient Health, Professional Case Management. 26(6), p. 298-303. https://doi.org/10.1097/NCM.0000000000000506

Klein, D. A., Paradise, S. L., & Goodwin, E. T. (2018) Caring for Transgender and Gender-Diverse Persons: What Clinicians Should Know, American Family Physician, 98(11), p. 645-653.

Korpaisarn, S., Safer, J. D., & Tangpricha, V. (2020) Gaps in transgender medical education among healthcare providers: A major barrier to care for transgender persons, Reviews in endocrine & metabolic disorders, 19(3), p. e271-275. https://doi.org/10.1007/s11154-018-9452-5

Main Page. (n.d.) Global Education Institute. WPATH. https://www.wpath.org/gei

National Center for Transgender Equality. (2007, January 16) Robert Eads, National Center for Transgender Equality. https://transequality.org/blog/robert-eads

Ravishankar, M. (2013, January 18) The Story About Robert Eads, The Journal of Global Health. https://archive.ph/20130914005716/http://www.ghjournal.org/jgh-online/the-story-about-robert-eads/

Rodriguez, A., Agardh, A., & Asamoah, B. O. (2017) Self-Reported Discrimination in Health-Care Settings Based on Recognizability as Transgender: A Cross-Sectional Study Among Transgender U.S. Citizens, Archives of Sexual Behavior, 47(4), p. 973-985. https://doi.org/10.1007/s10508-017-1028-z

Seelman, K. L., Colón-Diaz, M. J. P., LeCroix, R. H., Xavier-Brier, M, & Kattari, L. (2017) Transgender Noninclusive Healthcare and Delaying Care Because of Fear: Connections to General Health and Mental Health Among Transgender Adults, Transgender Health, 2(1), p. 17-28. https://doi.org/10.1089/trgh.2016.0024

Transgender Day of Rememberance. (2019, February 17) Remembering Our Dead: Tyra Hunter, https://tdor.translivesmatter.info/reports/1995/08/08/tyra-hunter_washington-dc-usa_04a01786

World Professional Association for Transgender Health. (2012) Standards of Care for the Health of Transsexual, Transgender, and Gender Nonconforming People. 7th ed. https://www.wpath.org/media/cms/Documents/SOC%20v7/SOC%20V7_English.pdf

Published on
3D Printers on Himmelfarb Library First Floor
3D Printers on Himmelfarb Library First Floor
©Leland Ashford Lanquist, 2022

3D printing has received a considerable amount of spotlight in the past decade, but much of the focus lies upon its value for engineering, prototyping, and manufacturing. What can 3D printing offer the field of medical sciences, and what innovations have healthcare professionals already developed using 3D printers? Let’s explore some of the ways 3D printing is able to support or advance the field of medical sciences.

To start with, the customizability of 3D printing offers opportunities to create models that fit the needs of individual students and their courses. Scholars such as AbouHashem et al at Macquarie University and Western Sydney University have studied the effectiveness of using models in education, all at a more affordable price than traditional anatomical models (AbouHashem et al, 2015). But why is 3D printing so much more useful than other approaches to developing educational models? 3D printed models can be developed and printed to suit individual education needs–for instance, one student may want to focus on the internal structures of the heart, but another may need practice with the arteries and veins and how they connect to the rest of the vascular system.

Additionally, while traditional medical models often (for the sake of mass-production) show the body at the peak of health, 3D printed models offer opportunities for physically handling case-study examples. With tools like Harvard’s FreeSurfer, which can transform CT and MRI scans in the form of DICOM files into STL files–files readable by 3D modeling software like Blender3D and AutoDesk Maya–it is possible to create a 3D printable object based off of medical imaging after a bit of work cleaning it up.

3D Printed Heart Model
3D Printed Heart Model
©Leland Ashford Lanquist, 2022

Aside from educational models, hospitals and medical science institutions have been able to make high-detail models with tactile realism that can be used for surgical training and preparation. One method of 3D printing, known as Fused Deposition Modeling (FDM), extrudes a string of plastic material known as filament through a heated nozzle to meld the layers together one at a time. Advanced FDM printers can use multiple different nozzles to print different colors and materials. This has allowed some professionals such as Watanabe et al to develop models with flexibility and texture that better matches the human body (Watanabe et al, 2021). Weidert et al have elaborated upon how 3D printed models of bone fractures can be used to prepare surgeons for pre-planning complex procedures (Weidert et al, 2019).

Another popularized process is known as “bioprinting.” Bioprinting is a method of 3D printing with cells and other biomaterials to imitate natural tissue. It’s easy to imagine how this could be applied to medical sciences if the technology becomes advanced and accessible enough: as a replacement for organ donation, as a supplement for skin grafts, as a hyper-realistic training tool for surgery preparation. Much of this is not yet feasible on a large scale, but some are becoming more of a reality year by year. For instance, some researchers, such as Keriquel et al, have managed to complete in vivo bioprinting (i.e.: directly printing into the body) bone substitutes in mice with certain bone defects (Keriquel et al, 2017).

If you would like to learn more about bioprinting, Kenneth Douglas’ book, Bioprinting: To Make Ourselves Anew, explains how bioprinting came to be, as well as how it all works, in terms accessible to a generalized audience (Douglas, 2021). For  a deep-dive into where bioprinting as a field might be headed in the future, you may be interested in reading Wei et al’s “The Bioprinting Roadmap,” which analyzes the successes, challenges, opportunities, and obstacles of bioprinting as of 2020 (Wei et al, 2020).

Some surgeons utilize 3D printing to develop customized implants and prosthetics for their patients. Since some of the more high-end 3D printers permit users to print objects made of metal alloys that are safe to be within the human body, healthcare professionals, such as Xu et al, have developed alloy-printed cervical spine reconstruction implants for Ewing’s sarcoma, a rare bone cancer found most commonly in adolescents. 

You can learn more about 3D printed implants by reading Krishna et al’s “Muskuloskeletal 3D Printing” from Rybicki and Grant’s 3D Printing in Medicine. This chapter also includes information about how the customizability of 3D printed prosthetic limbs allows for things such as light-weight, low-cost, and functional prosthetic hands for children that can scale with the natural growth of the patient, (Rybicki & Grant, 2017) which were reported on in more detail by Zuniga et al. (Zuniga et al, 2015) You may also find Christensen’s chapter in 3D Printing in Medicine, “3D Printing and Patient-Matched Implants” a worthwhile read. It covers methods such as using 3D printed patient-scanned models as a form to shape metal implants around prior to surgery, as well as the use of implantable biomaterial, tying in methods of bioprinting previously elaborated upon. (Rybicki & Grant, 2017)

3D printing has not just made advances on a large scale, 3D printing is also on the forefront of innovation within micro-devices like lab-on-a-chip, micro-needles, and more. High-end 3D printers allow researchers and healthcare workers to produce complex micrometer-sized objects such as micro needles and lab-on-a-chip devices, customized to their particular needs.

In terms of the applications of these micro-devices, one scenario might be a researcher using a microelectrode array to gather and track high-quality data about how a person’s muscle cells and neurons react to certain electrical stimuli. This can help pharmacologists better understand how human bodies react to certain drugs. This same device can also be used in the development of a movable prosthetic limb that is custom to the person who uses that prosthesis. 

Microneedles, on the other hand, are tools that allow healthcare professionals to deliver injectable materials into the skin in a way that is less painful and less frightening for patients with needle-phobia. They also produce less waste than their traditional needle counterparts. Researchers such as Kundu et al have published on the value of the production of these kinds of micro-devices in low-resource settings, even despite the high cost of the machines needed to produce them (Kundu et al, 2018). Other researchers such as Santana et al have discussed how micro-devices produced by 3D Printers might serve as a possible alternative to in vivo testing on animals in the future (Santana et al, 2020).

All of this is just a small slice of what 3D printing is capable of in the hands of healthcare professionals. As well, with 3D printing technology advancing, the sky is very swiftly becoming the limit of what is possible. From medical models to research devices, there is so much opportunity that comes with 3D printing for the field of health sciences. 

Want to learn more about 3D printing and even get involved?

Himmelfarb Library offers 3D printing services! While we may not be able to produce every one of the items described in this piece, our 3D printing services do support a wide array of patron projects and activities, from educational models to cookie cutters. It is also a great way to get early involvement with what may very well become standard practice in many aspects of healthcare in the future, so please do come check out the service if you are a patron! If you’d like to learn more about how you can get involved, you can read more about how to request a print in a previous blog post, and you’re welcome to reach out to Leland Ashford Lanquist (lalanquist@gwu.edu) Brian McDonald (bmcdonald@gwu.edu) if you have any questions. If you already know what you want to do, go ahead and submit a print request, which you can also find on our 3D printing guide!

References

AbouHashem, Y., Dayal, M., Savanah, S., & Štrkalj, G. (2015) The application of 3D printing in anatomy education, Medical Education Online, 20(1), https://doi.org/10.3402/meo.v20.29847

Autodesk. (n.d.) Maya Software. Autodesk. https://www.autodesk.com/products/maya/overview

Blender Foundation. (n.d.) Home of the Blender project - Free and Open 3D Creation Software. Blender3D. https://www.blender.org/

Christensen. J. (2017). 3D Printing and Patient-Matched Implants. In F. J. Rybicki & G. T Grant (Eds.) 3D printing in medicine: a practical guide for medical professionals, (pp. 85-95). Springer International Publishing.

Douglas, K. (2021). Bioprinting: to make ourselves anew. Oxford University Press.

Harvard University. (n.d.) Freesurfer. https://surfer.nmr.mgh.harvard.edu/

Himmelfarb Health Sciences Library. (n.d.) 3D Printing at Himmelfarb. https://guides.himmelfarb.gwu.edu/3DPrinting/

Keriquel, V., Oliveira, H., Rémy, M., Ziane, S., Delmond, S., Rousseau, B., Rey, S., Catros, S., Amédée, V., Guillemot, F., & Fricain, J. (2017).  In situ printing of mesenchymal stromal cells, by laser-assisted bioprinting, for in vivo bone regeneration applications. Scientific Reports, 7. https://doi.org/10.1038/s41598-017-01914-x

Krishna, S., Small, K., Maetani, T., Chepelev, L., Schwarz, B. A., & Sheikh, A. (2017). Musculoskeletal 3D Printing. In F. J. Rybicki & G. T Grant (Eds.) 3D printing in medicine: a practical guide for medical professionals, (pp. 71–84). Springer International Publishing.

Kundu, A., Ausaf, T., & Rajaraman, S. (2018) 3D Printing, Ink Casting and Micromachined Lamination (3D PICLμM): A Makerspace Approach to the Fabrication of Biological Microdevices, Micromachines, 9(2), https://doi.org/10.3390/mi9020085

Santana, H. S., Palma, M. S. A., Lopes, M. G. M.., Souza, J., Lima, G. A. S., Taranto, O. P., & Silva, J. L. (2020).  Microfluidic Devices and 3D Printing for Synthesis and Screening of Drugs and Tissue Engineering.  Industrial & engineering chemistry research, 59(9), 3794-3810. https://doi.org/10.1021/acs.iecr.9b03787

Watanabe, N., Yamamoto, Y., Fujimura, S., Kojima, A., Nakamura, A., Watanabe, K., Ishi, T., & Murayama, Y. (2021). Utility of multi-material three-dimensional print model in preoperative simulation for glioma surgery. Journal of Clinical Neuroscience, 93, 200–205. https://doi.org/10.1016/j.jocn.2021.09.017

Wei, S., Starly, B., Daly, A. C., Burdick, J. A., Groll, J., Skeldon, G., Shu, W., Sakai, Y., Shinohara, M., Nishikawa, M., Jang, J., Cho, D., Nie, M., Takeuchi, S., Ostrovidov, S., Khademhosseini, A., Kamm, R. D., Mironov, V., Moroni, L., Ozbolat, I. T. (2020). The bioprinting roadmap. Biofabrication, 12(2). https://doi.org/10.1088/1758-5090/ab5158

Weidert, S., Andress, S., Suero, E., Becker, C., Hartel, M., Behle, M., & Willy, C. (2019) 3D-Druck in der unfallchirurgischen Fort- und Weiterbildung: Möglichkeiten und Anwendungsbereiche, Der Unfallchirurg, 122(6), 444-451. https://doi.org/10.1007/s00113-019-0650-8

Xu, N., Wei, F., Liu, X., Jiang, L., Cai, H., Li, Z., Yu, M., Wu, F., & Liu, Z. (2016) Reconstruction of the Upper Cervical Spine Using a Personalized 3D-Printed Vertebral Body in an Adolescent With Ewing Sarcoma, Spine, 41(1), E50-E54. https://doi.org/10.1097/BRS.0000000000001179

Zuniga, J., Katsavelis, D., Peck, J., Stollberg, J., Petrykowski, M., Carson, A., & Fernandez, C. (2015) Cyborg beast: a low-cost 3d-printed prosthetic hand for children with upper-limb differences, BMC Research Notes, 8(1), 10-10. https://doi.org/110.1186/s13104-015-0971-9

Viewing Message: 1 of 1.
 Notice

This site uses cookies to offer you a better browsing experience. Visit GW’s Website Privacy Notice to learn more about how GW uses cookies.