Author: bsmith91

April 25 is  National DNA Day. It’s a day where researchers, teachers, students and the general public can learn more about the history of genomics and DNA, as well as learn about the advances researchers have made over the years as they seek to understand what DNA can reveal about our shared humanity and our individual traits. According to the National Human Genome Research Institute, “National DNA Day is a global movement to mobilize, energize and empower communities, educators and students to innovate, collaborate and discover the promise of our shared humanity and connection to the natural world.” National DNA Day commemorates two significant events in the history of DNA: the completion of the human genome project in 2003 and the discovery of the double helix in 1953. In recent years and with a deeper understanding of DNA, there has been a discrepancy between the general public’s perception of the usefulness of DNA and what this information actually means for humanity. By examining the rise in popularity of at-home ancestry testing kits, the role DNA plays in the legal system, and disease research and DNA, it’s clear that our understanding of the human genome will not provide simple answers to complex questions. Researchers and the public must balance our appreciation of DNA with the reality that this research only deepens ongoing conversations about humanity.

Over the past few years, there has been a significant increase in ancestry testing and companies such as 23 and Me or Ancestry.com allow individuals to map their genetic ancestry through a simple DNA test. Ancestry tests can connect long lost family members to one another. For people who do not have access to an extensive well-documented family history, such as many African-Americans, ancestry testing can shed light on people’s countries of origin. These testing kits can also encourage people to learn more about cultures and groups. Many of these tests provide people the opportunity to connect with each other in meaningful ways. But many researchers and critics point out the limitations of ancestry testing. Many testing companies rely on their own databases to compare and create user results. If these databases lack genetic information from certain populations or groups, then the ancestry testing results will not be an accurate representation of people’s family lineage. “Commercial ancestry testing is an unintended spin-off from basic research, but the basic research was designed to answer questions about population migration in a probabilistic manner and not to provide concrete and detailed genealogical information to individuals.” (Wailoo et al., 2013, p. 58) Ancestry testing can also lead people to believe our ethnicity or race can be segmented into neat and clear categories. Many scientists have stated there is no biological or scientific basis for race, yet these ancestry tests unintentionally suggest otherwise as they often use broad racial or ethnic categories that do not capture the true diversity across the world. 

Ancestry testing is a great way for people to connect with relatives they’ve lost contact with or for people to have some idea of where they may originate from. But it’s important these tests do not perfectly capture our family history and the initial results may change as ancestry testing companies expand their internal DNA databases.

One of the most popular ways in which DNA testing is used is in the realm of the legal system. Popularized by shows such as Law and Order or CSI, forensic science and DNA testing are often seen as pivotal aspects of any legal investigation. With the rise in DNA testing, many police investigators have successfully apprehended alleged suspects after a crime has been committed. Criminal cases that were opened for years were able to be closed once the collected DNA was analyzed in a lab. But there have been cases of innocent people being wrongfully accused and jailed when errors in DNA handling or testing caused investigators to chase alternative leads. “The problem, as a growing number of academics see it, is that science is only as reliable as the manner in which we use it—and in the case of DNA, the manner in which we use it is evolving rapidly.” (Shaer, 2009) DNA has a complex role in the legal system. It can provide a sense of certainty when law enforcement officers are investigating a case, but poor handling or lab standards can sometimes lead to wrongful convictions that are difficult to overturn. And there are cases where defense attorneys have relied on DNA analysis to free wrongfully convicted individuals. “Among them [ready to move beyond concerns of DNA use in criminal trials] were Dream Team members Barry Scheck and Peter Neufeld, who had founded the Innocence Project in 1992. Now convinced that DNA analysis, provided the evidence was collected cleanly, could expose the racism and prejudice endemic to the criminal-justice system, the two attorneys set about applying it to dozens of questionable felony convictions. They have since won 178 exonerations using DNA testing; in the majority of the cases, the wrongfully convicted were black.” (Shaer, 2009)

Advances in DNA and genetic research has allowed individuals to better track hereditary illnesses, thus giving them the opportunity to take early steps to address potential health concerns. Through genetic testing individuals can learn about potential inherited susceptibility to diseases such as certain types of cancers, certain blood disorders or respiratory diseases. In this realm, researchers have cautioned that this form of testing could potentially be misinterpreted by individuals seeking to link certain racial groups to certain inherited diseases. “It is in the area of disease studies that the relationship between race and genetics becomes the most susceptible to misinterpretation and distortion…Work carried out by geneticists Sara Tishkoff and others make it clear that sweeping conclusions about African Americans and disease-associated genetic variables are untenable.” (Wailoo et al., 2013, 59) While genetics can play a significant role in an individual’s susceptibility to a disease, other factors are just as significant and should be carefully studied and addressed. “For most diseases in the United States that differ in incidence by race, racial differences correspond to socio-economic or cultural differences. Most of the differences in incidence of asthma, hypertension, and heart disease by race can be explained by differences in income and environmental risk factors.” (Wailoo et al., 2013, 60) The role that genetics play in determining a person’s susceptibility to a disease is important, but should be considered alongside other variables and it’s important to avoid sweeping generalizations. 

The discovery of DNA and the gene sequencing process allows humanity to better understand our makeup and answer some questions about our origins. In the conversations on who we are, where we come from and where we can go, DNA has an important voice that provides a unique insight into our inner workings. For this National DNA Day the general public should continue to learn about and engage with DNA research, while also remaining aware that DNA research will raise as many questions as it does answers. “Science is technical and difficult to comprehend but that does not absolve scientists of the responsibility to inform the public about their work, explain their methods and their rigor, admit the limitations and areas of controversy and uncertainty, and examine its wider relevance. Conversely, the difficulty of understanding and digesting science does not absolve the general public from acknowledging its importance and its contributions.” (Wailoo et al., 2013, 62) To learn more about National DNA Day or the Human Genome Project, please explore the National Human Genome Research Institute website.

Works Cited:

National Human Genome Research Institute. (n.d.). National DNA Day. Retrieved April 22, 2022. https://www.genome.gov/dna-day

Shaer, M. (2016, June). The False Promise of DNA Testing. The Atlantic. https://www.theatlantic.com/magazine/archive/2016/06/a-reasonable-doubt/480747/ 

Wailoo, K., Nelson, A., & Lee, C. (Eds.). (2012). Genetics and the Unsettled Past: The Collision of DNA, Race, and History. Rutgers University Press. http://www.jstor.org/stable/j.ctt5hj79f