News

Congratulations to Haorong Li (2nd year PhD student) on his recent publication being featured on the journal cover of JASMS!

This is the first Hao Lab Journal Cover and an invited contribution to the emerging investigator focus issue! 
Haorong Li, Ashley M. Frankenfield, Ryan Houston, Shiori Sekine, and Ling Hao, “Thiol-Cleavable Biotin for Chemical and Enzymatic Biotinylation and Its Application to Mitochondrial TurboID Proteomics“, Journal of the American Society for Mass Spectrometry, 2021. https://pubs.acs.org/doi/10.1021/jasms.1c00079

Dr. Hao is guest editing a special Methods Collection in JOVE (Journal of Visualized Experiment) on ” Understanding the Central Nervous System by Mass Spectrometry”

Most central nervous system (CNS) disorders are currently incurable due to our limited understanding of disease mechanisms and the challenges of CNS drug development. MS-based techniques are widely applied to decipher the molecular mechanisms of neurological disorders and discover biomarkers and therapeutic targets for brain diseases.

JoVE is the first and only peer-reviewed scientific methods video journal, aimed at increasing the visibility and reproducibility of research, and the world-leading producer and provider of science videos.


This Method Collection will highlight recent advancements and methods in various MS techniques and MS-based analyses of diverse biomolecules, including but not limited to MS-based proteomics, peptidomics, metabolomics, lipidomics, MS-imaging, single-cell analysis, and biomarker discovery, with a special focus in studying the CNS. The goal is to provide video-based protocols and promote best practices in cutting-edge MS-based methodologies, assisting the researchers in the field to advance new technologies and deepen our understandings of the CNS. Abstract submission is now open for this special method collection.

Hao Lab received a 5-year NIH R01 grant ($2Million) to support the research in “Developing Mass Spectrometry Strategies to Decipher the Dynamic Lysosomal Dysfunctions in Frontotemporal Dementia” !

The research aims to develop novel mass spectrometry-based bioanalytical chemistry techniques to understand the disease mechanisms, and discover potential therapeutic targets for frontotemporal dementia, the most common form of dementia for people under age 60. This grant will support a number of major research projects in the Hao Lab for the next five years! Congratulations to Dr. Hao and all the Hao Lab members!

Hao Lab members presented at the virtual US HUPO (Human Proteome Organization) Annual Conference

Ashley and Haorong (2nd year PhD students) attended half-day proteomics workshop to get additional training on protein-protein interaction and chemical cross-linking at US HUPO. Ashley gave a lightening talk and presented her poster on Tuesday, titled:” Proteomic Evaluation of the Dynamic Protein Turnover in Human iPSC-derived Neurons“. Haorong presented his poster on Tuesday, titled “MS-based Proteomics and Metabolomics of MELAS Syndrome“.
Dr. Hao chaired the Parallel Session, Omics of the Central Nervous System, on Monday and gave a talk on Friday titled: “Cleavable Biotin-Enabled Proximity Labeling Proteomics” at the New Strategy of Interactomics in Structural Biology session.